PSA-ACT and Free PSA

Assessing PSA Controls

  • An ideal Free PSA/Total PSA ratio is approximately 30%.*
  • Controls containing varying amounts of Free PSA and PSA-ACT are represented by the ratios of Free to Total PSA in this chart.
  • Control material with higher percent ratios of Free PSA to Total PSA may not be adequately monitoring the performance of the Total PSA Assay.

Ensure that your laboratory is truly monitoring the long-term precision and accuracy of your assays through a control material that contains all of the sub-fractions of the analytes being tested.

% Ratio Free PSA/Total PSA FDI vs. Competitor Controls between Platforms†

% Ratio Free PSA/Total PSA FDI vs. Competitor Controls between Platforms

† % PSA data was calculated using assigned value information found in respective control product package inserts

* Chun, Felix K.-H., Hutterer, Georg C., et al. (2007). Distribution of prostate specific antigen (PSA) and percentage free PSA in a contemporary screening cohort with no evidence of prostate cancer. BJU Journal Compilation, 100, 37-41.